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What Happened: The study was a randomized, double-blind, placebo-controlled trial using Spartalizumab — an investigational monoclonal antibody, alongside Tafinlar and Mekinist. The evaluation was conducted in three parts and the declared results were from the final stages of testing, Novartis said. Why It Matters: The company noted it intended to continue Spartalizumab development, despite negative clinical trial results. Price Action: Novartis shares closed 0. The stock gained 0. Novartis AG announced on Saturday that its investigational spartalizumab immunotherapy drug combined with Tafinlar and Mekinist therapies failed to meet its primary endpoint in a late-stage trial for the treatment of a type of advanced skin cancer. The trial was conducted among untreated patients with unresectable or metastatic stage IV BRAF V mutation-positive cutaneous melanoma, compared to the treatment of Tafinlar and Mekinist alone.

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It has a single hp, V-8 turbocharged , water-cooled, diesel engine, an improvement over the twin gasoline engines installed in the BTR and BTR vehicles. The reconfigured rear portion of the hull accommodates the new, single engine. The Soviets removed the roof chamfers of the modified BTR, raised the rear, and squared off the rearward-sloping engine compartment.

This allows the This high angle of fire is useful in engaging targets on steep slopes, in urban fighting, and for engaging low slow flying air targets. The forward firing ports now sit in angled recesses, which allows infantry to fire to the front of the vehicle. The redesigned side doors are split horizontally. The upper portion opens forward; this gives dismounting troops some protection against small arms fire from the front of the vehicle.

The lower portion opens down, forming a step. Six smoke grenade projectors are mounted on the rear of the turret. The Soviets have retrofitted some BTRs with several of the improvements incorporated into the BTR, including the high-angle-of-fire turret.

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